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VOLUME 1 , ISSUE 1 ( January-March, 2017 ) > List of Articles


An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients

Harbans Singh, Rajesh Sannd, Laxman W Bhurke, Krishna Kumari, Renu Singh, SK Vedi, Bharti  , MM Padhi

Citation Information : Singh H, Sannd R, Bhurke LW, Kumari K, Singh R, Vedi S, B, Padhi M. An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients. J Res Ayurvedic Sci 2017; 1 (1):25-33.

DOI: 10.5005/jp-journals-10064-0004

License: CC BY 3.0

Published Online: 00-03-2017

Copyright Statement:  Copyright © 2017; Jaypee Brothers Medical Publishers (P) Ltd.



Vatarakta vis-à-vis gout is a common condition in both primary care and specialist practice. Gout is a systemic disease characterized by manifestations of chronic under­lying hyperuricemia, resulting in the deposition of monosodium urate crystals in various tissues. Gout is the most common of the crystal induced arthritis due to disturbed uric acid metabolism and precipitation of urate crystals in extracellular space of joints, periarticular tissue, bones, and other organs.

Aim and objective

To explore the therapeutic efficacy and safety of Amrita Guggulu and Pinda Taila in the management of hyperuricemia in gout (Vatarakta) patients.

Materials and methods

A total of 100 cases (25–65 years) of primary gouty arthritis fulfilling the diagnostic criteria as recommended by the American College of Rheumatology were selected for the present study from outpatient department of the Central Ayurveda Research Institute for Respiratory Disorders Patiala and Regional Ayurveda Research Institute for Urinary Disorders, Jammu, India, irrespective of their sex, religion, and socioeconomic status. Only those patients who presented themselves with at least 6 of 12 criteria of American College of Rheumatology (1977) were selected for the clinical trial. Amrita Guggulu was given 1000 mg twice daily orally and Pinda Taila was applied locally 10 mL twice daily for 84 days.


The trial therapy was assessed based on the improvement in clinical features, Visual Analog Scale (VAS) score, Patient's Global Assessment Scale score, Physician's Global Assessment Scale Score, SF-36 Health Survey Score for quality of life (QOL), and biochemical parameters. Each patient was subjected to routine blood test, serum uric acid, liver function tests, and renal function tests before treatment, after 28 days of treatment, and after 84 days of treatment. The trial combination showed statistically significant improvement in the clinical manifestations, QOL as well as reduction in marker of hyperuricemia, i.e., serum uric acid; the mean serum uric acid at the baseline was 7.76 mg/dL, which was reduced to 6.50 mg/dL after the trial period of 84 days. There was also decrease in the level of VAS score, Patient's Global Assessment Scale score, and Physician's Global Assessment Scale score. There were no impairment in liver function test and renal function test, indicating the good safety profile of trial therapy.


Hence, Amrita Guggulu and Pinda Taila drug combination is an effective and safe remedy for gouty arthritis (Vatarakta) patients.

How to cite this article

Singh H, Sannd R, Bhurke LW, Kumari K, Singh R, Vedi SK, Kumar A, Bharti, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients. J Res Ayurvedic Sci 2017;1(1):25-33.

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  1. New insights into the epidemiology of gout. Rheumatology (Oxford) 2009 May;48Suppl 2:ii2-ii8.
  2. Gout – updated. Med Update 2012;22:674-679.
  3. Gout. Lancet 2010 Jan;375(9711):318-328.
  4. Forbes 2015;11:02.
  5. Central role of complement membrane attack complex in monosodium urate crystal-induced neutrophilic rabbit knee synovitis. Arthritis Rheum 2004 Aug;50(8):2633-2639.
  6. Pathogenesis of crystal-induced inflammation. Curr Rheumatol Rep 2001 Feb;3(1):36-41.
  7. Singh Harish Chandra, 2nd Part, Chaukhambha Orientalia, Varanasi Re-print 2012, Chikitsasthana 29th Chapter, Shloka No. 10-11, p. 773.
  8. I, Ni dansthana – 1st Chapter, Shloka No. 48, p. 463.
  9. Singh Harish Chandra, 2nd Part, Chaukhambha Orientalia, Varanasi Re-print 2012, Chikitsasthana 29th Chapter, Shloka No. 20-21, p. 776.
  10. Braunwald,Eugene Kasper,Dennis L. Hauser,Stephen L. Longo,Dan L Larry Jameson,J. Loscalzo,Joseph Harrison's Principles of Internal Medicine, 17th Edition, Vol.-II, McGraw-Hill Companies, United States of America, 2008, pp. 2166.
  11. Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8. J Leukoc Biol 1997 Oct;62(4):444-449.
  12. Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum 2002 Oct;46(10):2765-2775.
  13. Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest 1991 Apr;87(4):1375-1381.
  14. Pathogenesis of gout. Ann Intern Med 2005;143(7):499-516.
  15. Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis. J Clin Rheumatol 2013 Jan;19(1):19-29.
  16. Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events. Arthritis Rheum 2002 Jun;46(6):1643-1650.
  17. Update on gout and hyperuricemia. Int J Clin Pract 2010 Feb;64(3):371-377.
  18. Clinical practice. Gout. N Engl J Med 2011;364(5):443-452.
  19. Preliminary studies on anti-inflammatory activity of Zingiber officinale Rosc, Vitex negundo Linn and Tinospora cordifolia (Willid) Miers in albino rats. Indian J Pharm 1999;31:232-233.
  20. Screening of anti inflammatory activity of certain indigenous drugs on carragenin induced hind paw oedema in rats. Bull Medico Ethnobot Res 1980;1(2):12.
  21. Perianayagam BJ, Joseph A, Christina AJM. Anti-inflammatory activity of ethanol an aqueous extracts of Emblica officinalis Gaertn fruits. Hamdard Medicus 2003;46:75-78.
  22. Anti-arthritic and disease modifying activity of Terminalia chebula Retz. in experimental models. J Pharm Pharmacol 2010 Dec;62(12):1801-1806.
  23. Indian medicinal plants as reservoir of protective phytochemicals. Teratog Carcinog Mutagen 2003;23 (Suppl 1):295-300.
  24. The Ayurvedic medicines Haritaki, Amala and Bahira reduce cholesterol-induced atherosclerosis in rabbits. Int J Cardiol 1988 Nov;21(2):167-175.
  25. Hypolipidemic activity of three indigenous drugs in experimentally induced atherosclerosis. Int J Cardiol 1998 Dec;67(2):119-124.
  26. Hepatoprotective and immunomodulatory properties of Tinospora cordifolia in CCL4 intoxicated mature albino rats. J Toxicol Sci 2002 Aug;27(3):139-146.
  27. Modulation of Kupffer cell activity by Tinospora cordifolia in liver damage. J Postgrad Med 1994 Apr-Jun;40(2):65-67.
  28. Antioxidant activity of Tinospora cordifolia roots in experimental diabetes. J Ethnopharmacol 1999 Jun;65(3):277-281.
  29. Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats. Phytother Res 2001 May;15(3):213-218.
  30. Guggulsterone inhibits NF-κB and IκBα kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem 2004 Nov;279(45):47148-47158.
  31. Nodulocystic acne: oral gugulipid versus tetracycline. J Dermatol 1994 Oct;21(10):729-731.
  32. Inhibition of HIV-1 integrase by galloyl glucoses from Terminalia chebula and flavonol glycoside gallates from Euphorbia pekinensis. Planta Med 2002 May;68(5):457-459.
  33. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull 2005 Sep;28(9):1639-1644.
  34. Isolation of chebulic acid from Terminalia chebula Retz. and its antioxidant effect in isolated rat hepatocytes. Arch Toxicol 2007 Mar;81(3):211-218.
  35. Adaptogenic properties of six Rasayana herbs used in Ayurvedic medicine. Phytother Res 1999 Jun;13(4):275-291.
  36. Nodulocystic acne oral Guggulu lipid versus tetracycline. J Dermatol 1994; 21: 729.21.
  37. Antioxidant activity of Guggulu sterone, the active principle of guggulu lipid from Commiphora mukul. Journal of Medicinal Aromatic Plant Sciences 2002; 24: 370. 22.
  38. Hyperlipidemic and antioxidant effect of Commophora mukul as an adjunct to dietary therapy in patients with hypercholesteremia. Cardiovascular Drug Therapy 1994; 8(4): 659.
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