Introduction: A clinical case report is a detailed narration that describes a medical problem for medical, scientific, or educational purposes, experienced by a medical practitioner in one or several patients. The case report (CARE) guidelines are designed to increase the completeness, accuracy and transparency of the case reports and also provide early signals of benefit, harm and value. Though many of the authors are publishing Ayurvedic case reports based on CARE guidelines but there is no uniformity of reporting Ayurvedic parameters among them. And till date no reporting guidelines based on Ayurvedic framework exists for Ayurvedic case reports. Diagnostic assessment and therapeutic intervention aspects of CARE checklist require Ayurvedic Specific Extension guidelines for Case reporting (AYUR-CASE). Materials and methods: All the relevant material for developing Ayurvedic specific extension to the CARE clinical case reporting guidelines are collected from the major Ayurveda texts with their commentaries. Electronic databases such as “PubMed,” “Google scholar search” and “Google search” were also used. Results: A list of important diagnostic as well as therapeutic aspects viz., Panchalakshana nidana, Ashtasthana pariksha, Dashvidh pariksha, Sodhana, Shamana, Rasayana, etc., mentioned in various samhitas are collected. As the related information is extensively documented in Ayurveda scriptures so it is critical to prioritize and select the necessary parameters, for which expert consensus need to be arrived at and hence the techniques like Delphi can be adopted for successful development of the AYUR-CASE guidelines. Conclusion: Ayurveda practice in the present day gives more valid results that are reproducible when the clinical approach and research protocol are based on fundamental principles of Ayurveda rather than the modern science. Hence to start a new chapter in the field of Ayurvedic Research—AYUR-CASE guidelines for case reporting has been proposed. These guidelines will help to achieve complete, accurate and transparent qualities of reporting clinical case reports in Ayurveda.