Clinical Efficacy/Safety of Therapeutic Combination; Kshirbala Taila Matra Basti, Vatari Guggulu, Maharasnadi Kwatha and Narayan Taila in the Management of Osteoarthritis Knee (Sandhivata): A Prospective Open Label Study
Citation Information :
Namburi US, B. Clinical Efficacy/Safety of Therapeutic Combination; Kshirbala Taila Matra Basti, Vatari Guggulu, Maharasnadi Kwatha and Narayan Taila in the Management of Osteoarthritis Knee (Sandhivata): A Prospective Open Label Study. J Res Ayurvedic Sci 2018; 2 (2):90-98.
Introduction: Osteoarthritis (OA) knee is the most frequent joint disease encountered in the clinical practice and a leading cause of disability in the elderly. It is a chronic degenerative disorder of multi-factorial etiology characterized by loss of articular cartilage, hypertrophy of bone at the margins, subchondral sclerosis and range of biochemical and morphological alterations of the synovial membrane and joint capsule. The clinical presentation of OA is similar to Sandhivata described under Vatavyadhi in Ayurveda.
Objectives: To evaluate the clinical efficacy and safety of Kshirbala Taila Matra Basti chikitsa along with Vatari Guggulu, Maharasnadi Kwatha internally and local application of Narayan Taila in the management of OA knee.
Materials and Methods: A prospective, interventional, openlabel study was carried out at the Regional Aryuveda Research Institute for Mother and Child Health (RARIMCH), Nagpur. Sixty patients in the age group 35-65 years with primary OA of knee joint fulfilling the diagnostic criteria were enrolled. A combination of Kshirbala Taila Matra Basti for 27 days in three courses (each of 9 days) along with Vatari Guggulu, Maharasnadi Kwatha orally and local application of Narayan Taila locally, was administered for 12 weeks. Subjects were followed every fortnightly during treatment and after 4 weeks of completion of treatment. Assessment was done at every two weeks on the basis of the change in pain, stiffness and physical function using the validated modified western ontario and McMster Universities osteoartharitis index (WOMAC) questionnaire, visual analog scale (VAS) scale and global Assessment of disease activity scale.
Observations and Results: A significant reduction in total WOMAC score (p-value < 0.001) was observed after the treatment of 12 weeks and also at the end of 16th week. The mean knee joint pain score assessed on VAS was 8.05 which reduced significantly to 5.52 on 84th day and 5.37 on follow-up (p < 0.001). The mean score of global assessment of disease activity at baseline was 80.17, which reduced to 51.17 on 84th day and 49.00 on follow up (p < 0.001). No adverse events were reported during the course of treatment.
Conclusion: The therapeutic regimen Kshirabala Taila, Matra Basti and Vatari Guggulu, Maharasnadi Kwatha along with topical application of Narayana Taila is safe and significantly effective (P < 0.001) in all the cardinal symptoms of OA of knee joint.
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