Citation Information :
Sharma B S, Srinivas P, Venkateswarlu G, Marlewar S, Das B, Ravte R, Wakode VB. Clinical Safety of Selected Ayurvedic Formulations as Rasayana in Apparently Healthy Elderly Persons: A Pharmacoepidemiological Perspective. J Res Ayurvedic Sci 2018; 2 (2):122-131.
Introduction: Rasayana drugs are a g roup of medicinal preparations having Balya (improving physical strength), Agnivardhaka (stimulating digestive activity), Medhya(improving intellect), Ojovardhaka (enhancing immunity) and Vayasthapana(delaying ageing) properties. Rasayana therapy (Rejuvenating group of medicines) aims specially at the promotion of strength and vitality by replenishing rasa and other dhatus. Objective: Critical analysis and presentation of clinical safety and efficacy outcomes of classical Ayurvedic formulations, viz. Ashwagandhadi leha, Brahma Rasayana and Chyavanaprasha in apparently healthy elderly persons, generated through multicentre open label studies conducted at different CCRAS centres.
Materials and Methods: Analysis of data collected from three different clinical studies that had been completed in peripheral institutes of Central Council for Research in Ayurvedic Sciences (CCRAS), were critically evaluated to assay the safety profile of three formulations, namely Ashwagandhadi leha, Brahma Rasayana and Chyavanaprasha. Clinical safety assessments were done through analyzing liver function tests (LFT) and renal function tests (RFT) before and after the administration of rasayana. Parameters like hamilton depression rating scale, PGI memory scale and world health organization quality of life instrument-abbrivated version (WHO QOL-BREF)scale were also assessed before and after administration of Rasayana. Paired t-test was used to compare mean change from baseline to end of the trial period. Drug compliance and adverse events (AE)/adverse drug reaction (ADR)s, if any were also noted.
Conclusion: The findings in the three different clinical studies clearly reveal that Ashwagandhadi leha, Brahma Rasayana and Chyavanaprasha are clinically safe, tolerable and effective in apparently healthy elderly persons.
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