Journal of Research in Ayurvedic Sciences

Register      Login

VOLUME 2 , ISSUE 2 ( April-June, 2018 ) > List of Articles

SHORT COMMUNICATION

Clinical Efficacy of an Ayurvedic Formulation in the Management of Dengue: A Short Report

Buduru S Prasad, Veerappa A Kothivale, Rekha Patil, Sukumar Nandigoudar, Bhagwan S Sharma, S.L Hoti, Manoj Nesari

Keywords : Dengue, Thrombocytopenia,Ayurveda

Citation Information : Prasad BS, Kothivale VA, Patil R, Nandigoudar S, Sharma B S, Hoti S, Nesari M. Clinical Efficacy of an Ayurvedic Formulation in the Management of Dengue: A Short Report. J Res Ayurvedic Sci 2018; 2 (2):136-139.

DOI: 10.5005/jp-journals-10064-0049

License: CC BY-NC 3.0

Published Online: 00-06-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Dengue is potentially a fatal illness prevalent in the tropical regions of the world, and an outbreak of this lead to serious complications like dengue shock syndrome and dengue hemorrhagic syndrome. Development of a precise solution/ formulation for dengue is highly essential and is the need of the hour. In this endeavor, a polyherbal ayurvedic formulation was identified and used as an adjuvant to the existing treatment protocol by World Health Organization (WHO) (standard care) for dengue. The objective of this study was to observe the platelet trends and prevention of complications in dengue patients and also to evaluate the improvement in clinical signs and symptoms with minimum recovery days. Materials and Methods: An observational retrospective cohort design was adopted. Thirty-five patients of either sex, of age between 16 and 60 years, were selected from Shri BMK Ayurveda Mahavidyalaya, JN Medical College and Dr. Prabhakar Kore Hospital and Medical Research Centre of KLE Higher Education and Research Centre, Belagavi. The case records belonging to dengue patients who were confirmed by positive NS-1 antigen or IgM test with thrombocytopenia, and classical features of dengue who were treated with standard care suggested by WHO along with Polyherbal Ayurvedic formulation decoction in the dose of 40 ml twice a day for ten days and were followed up further for atleast four days. Results: Platelet count has increased in all patients. Significant progressive increase in platelet count was observed from 1st to 5th day which was statistically significant when value of 3rd day was compared to that of 5th day. Early improvement in clinical features of dengue was observed, and no case of complications was noticed. Conclusion: The polyherbal Ayurvedic formulation decoction and WHO prescribed standard care is seen as a good adjuvant for dengue which showed a potential increase in platelet count and speedy recovery of patients.


PDF Share
  1. Mustafa MS, Rasotgi V, Jain S, Gupta V. Discovery of fifth serotype of dengue virus (DENV05): A new health dilemma in dengue control. Med J Armed Forces India 2015;71(1):67-70.
  2. Messina JP, Brady OJ, Scott TW, Zou C, Pigott DM, Duda KA, Bhatt S, Katzelnick L, Howes RE, Battle KE, et.al. Global spread of dengue virus types: mapping the 70 years history. Trends Microbiol. 2014;22(3):138-146.
  3. Bhatt S, Gething PW, Brady OJ, Messina JP, Farlow AW, Moyes CL, Drake JM, Brownstein JS, Hoen AG, Sankoh O, et.al. The global distribution of and burden of dengue. Nature 2013;496(7446):504-507.
  4. World Health Organisation: Comprehensive Guidelines for Prevention and Control of Dengue and Dengue Hemorrhagic Fever. Revised and Expanded Edition. New Delhi: World Health Organization, Regional Office for South-East Asia, 2011.
  5. National Guidelines for Clinical management of dengue fever. By National Vector Born Disease Control Programme. World Health Organization; 2014. Available on: http:// nvbdcp.gov.in/Write ReadData/l892s/Dengue-National- Guidelines-2014.
  6. Nathan MB, Dayal-Drager R, Guzman M. Chapter 1: Epidemiology, Burden of Disease and Transmission. In: Ciceri K, Tissot P, et. al. Editors. Dengue guidelines for diagnosis, treatment, prevention and control - New edition. Geneva: World Health Organization; 2009.p.11.
  7. Jayashree K, Manasa GC, Pallavi O, Manjunath GV. Evaluation of platelets as predictive parameters in dengue fever. Indian J Hematol Blood Transfuse. 2011;27(3):127-30.
  8. Sharma RK, Dash B; editor. Agnivesa's Charaka Samhita, Chikitsa Sthana, Ch. 3; Vol. III. Varanasi: Chaukhambha Publications.138.
  9. Bandyopadhyay S, Lum LC, Kroeger A. Classifying dengue: a review of the difficulties in using the WHO case classification for dengue haemorrhagic fever. Trop Med Int Health. 2006;11(8):1238-55.
  10. Deen J, Lum L, Martinez E, Tan LH. Chapter 2: Clinical management and delivery of clinical services. In: Ciceri K, Tissot P, et. al. Editors. Dengue guidelines for diagnosis, treatment, prevention and control - New edition. Geneva: World Health Organization; 2009.p.27-8.
  11. Rao GP; translator. Sharngadhara Samhita of Sharangadharachaya, Chapter 2. New Delhi: Chaukhambha Publications.71.
  12. Tripathi B, Deshpande P, editor. Charak Samhita of Agnivesha, Chikitsa Sthana, Chapter 3 (Volume II). Varanasi: Chaukhamba Surbharati Prakashan. 218.
  13. Tripathi B, Deshpande P, editor. Charak Samhita of Agnivesha, Chikitsa Sthana, Chapter 3 (Volume II). Varanasi: Chaukhamba Surbharati Prakashan. 237.
PDF Share