Journal of Research in Ayurvedic Sciences

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VOLUME 2 , ISSUE 4 ( October-December, 2018 ) > List of Articles

RESEARCH ARTICLE

Clinical Efficacy and Safety of Brahma Rasayana in Apparently Healthy Elderly Persons: A Prospective Multicenter Open-label Study

Banamali Das, Rohit Kumar Ravte, G Venkateswarlu, Purnendu Panda

Keywords : Dhatu Poshana, Hamilton depression rating scale,Brahma Rasayana,Rasa Dhatu

Citation Information : Das B, Ravte RK, Venkateswarlu G, Panda P. Clinical Efficacy and Safety of Brahma Rasayana in Apparently Healthy Elderly Persons: A Prospective Multicenter Open-label Study. J Res Ayurvedic Sci 2018; 2 (4):217-224.

DOI: 10.5005/jp-journals-10064-0061

License: CC BY-NC 4.0

Published Online: 00-00-0000

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Rasayana therapy is one of the branches of Ayurveda, which aims at promoting the excellence of Dhatu, improving inherent defense mechanisms in our body, and improving general health. Aim: To assess the clinical efficacy and safety of Brahma Rasayana in apparently healthy elderly persons. Materials and methods: The clinical study was undertaken at three peripheral institutes in different geographical areas. One hundred and eighty apparently healthy elderly persons fulfilling the inclusion criteria were enrolled in the study. Brahma Rasayana was administered orally in the dose of 15 grams twice a day on empty stomach with lukewarm milk for a period of 12 weeks (84th day). Parameters, like the Hamilton depression rating scale, PGI Memory Scale, WHO Quality of Life-BREF Scale, hematological parameters, lipid profile, liver function tests, renal function tests, thyroid stimulating hormone (TSH), serum calcium, and serum vitamin D3 level, were assessed before and after the administration of therapy. The paired t test was applied to compare mean changes from baseline to the 84th day. Results: A statistically significant effect (p < 0.0001) was observed at the end of the 84th day on all the four domains of the WHOQOL-BREF score, PGI Memory Scale, Hamilton depression rating scale, and chief complaints at the end of 12 weeks, compared with the baseline. Nonsignificant changes in blood parameters were obtained, proving the safety of the test drug. Also, the significant increase in the serum vitamin D3 level and decrease in the fasting blood sugar level were observed. Conclusion: Brahma Rasayana was found to be effective, safe, and tolerable in apparently healthy elderly volunteers.


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