Citation Information :
Kale K, Bharati PL, Yadav B, Suryawanshi M, Ratha KK, Sharma BS. Clinical Efficacy and Safety of Kushmandaka Rasayana in the Management of Chronic Bronchitis: A Prospective Open Label Multicenter Study. J Res Ayurvedic Sci 2018; 2 (4):225-232.
Background: Prevalence of chronic bronchitis is increasing as a part of urbanization and increased pollution. Failure of timely recognition of the condition often causes worsening of the disease. In Ayurveda, the symptoms of chronic bronchitis may be compared with those of Kaphaja Kasa. Kushmandaka Rasayana is a medicine that is commonly used in respiratory diseases owing to its Rasayana effect. Objectives: To evaluate the clinical efficacy and safety of Kushmandaka Rasayana in chronic bronchitis. Materials and methods: A prospective, open-label multicenter study was carried out in three peripheral centers of the Central Council for Research in Ayurvedic Sciences (CCRAS). A total of 193 patients with chronic bronchitis (Kaphaja Kasa) satisfying the selection criteria were enrolled from the outpatient department of these centers and were administered with 10 g of Kushmandaka Rasayana twice daily with lukewarm water for 12 weeks, and the patients were followed up, every two weeks up to the 12th week and at the 14th week (without medication follow-up). Changes in the symptoms, clinical COPD questionnaire (CCQ), and forced expiratory volume in the first second (FEV1%), were assessed every 14 days till 12 weeks and at the end of 14 weeks and were compared with baseline data. A p value of <0.05 was considered as significant. Safety assessment was done by analyzing liver function test (LFT) and renal function test (RFT) parameters before and after the trial. Result: Statistically significant improvement was observed in clinical symptoms, FEV1, and CCQ questionnaire without any adverse drug reactions (ADR)/adverse events (AE). All safety parameters were within normal limits during the entire trial.