A 31-year-old woman presented with uterine fibroid of 12.3 mm diameter in right lateral uterine wall and a cyst of 30 mm diameter in left ovary. She was intended to treat with some Ayurvedic formulations. Fibroids are the abnormal growths that develop in a woman\'s uterus. Sometimes these tumors are quite large and cause severe abdominal pain and heavy periods. In other cases, they cause no signs or symptoms at all. The growths are typically benign or noncancerous. The cause of fibroids is unknown. Fibroids are also called leiomyomas or myomas. Ayurvedic drugs have been proved useful for these manifestations. The case was treated for 14 months with a combination of different Ayurvedic drugs to alleviate symptoms and reduce the size of fibroid. Patient came with the complaint of excessive menstrual bleeding with pelvic pain and was diagnosed with uterine fibroid by ultrasonography (USG). This patient of uterine fibroid, diagnosed as Granthi was treated with Pradarantak rasa, Kanchnar guggulu, Arogyavardhini vati, Kumaryasava, Ashokarishta, and Pushyanuga churna during the treatment. Only oral Ayurvedic drugs were used during the treatment. Patient\'s condition was assessed for symptoms of uterine fibroid which was completely relieved. No evidence of uterine fibroid was seen in USG; therefore, it indicates the case of uterine fibroid successfully and completely cured with Ayurvedic treatment. Surgical removal of uterine fibroid or cyst is the only curative treatment in contemporary modern medical science. In Ayurveda, it may be successfully treated with oral Ayurvedic drugs and without surgical intervention.