Journal of Research in Ayurvedic Sciences

Register      Login

VOLUME 3 , ISSUE 3 ( July-September, 2019 ) > List of Articles

ORIGINAL RESEARCH ARTICLE

Clinical Evaluation of Kalyanaka Ghrita in the Management of Cognitive Deficit in Children

GV Ramana, Hemant Kumar Gupta, Srinibash Sahoo, Shweta Chaudhary

Keywords : Buddhi mandya, Cognitive deficit, Kalyanaka Ghrita, Modified mini-mental status examination, Smritidaurbalya,Binet Kamat test

Citation Information : Ramana G, Gupta HK, Sahoo S, Chaudhary S. Clinical Evaluation of Kalyanaka Ghrita in the Management of Cognitive Deficit in Children. J Res Ayurvedic Sci 2019; 3 (3):85-91.

DOI: 10.5005/jras-10064-0086

License: CC BY-NC 4.0

Published Online: 00-09-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: Cognitive deficit denotes the condition characterized by impairment in the cognitive and intellectual functions. In children, it is usually detected in early schooling, wherein the children lag in processing of information including thinking, memory, perception, motivation, skilled movements and language. Aim: The present study was conducted to evaluate the efficacy of Kalyanaka Ghrita in the management of cognitive deficit in children. Materials and methods: A prospective, open-label study was carried out in 40 participants clinically diagnosed as cognitive deficit by administering Kalyanaka Ghrita (6 g) twice daily after food along with lukewarm water for a period of 90 days. The parameters used to assess intelligence quotient (IQ) included Binet Kamat test (BKT), and modified mini-mental status examination (MMMSE). The participants were assessed periodically at baseline (zero day), on 30th, 60th, and 90th day. Parental perception was obtained at the end of the trial. Paired sample t test was used to compare mean change in values from baseline score to the 90th day score. Results: On comparison of the baseline scores with that at the end of the 90th day showed a statistically significant improvement in BKT and MMMSE scores (p < 0.001). No significant changes were observed in laboratory parameters. Conclusion: Based on the results obtained at the end of the study, it can be interpreted that Kalyanaka Ghrita is safe and effective in children with cognitive deficit.


PDF Share
  1. Stanley C, Ward LM, Enns JT. Sensation & Perception. 5th ed., Harcourt Brace; 1999. p. 9. ISBN 0-470-00226-3.
  2. Fried Y, Josseph A. Paranoia: A Study in Diagnosis (Boston Studies in the Philosophy and History of Science), vol. 50, Dordrecht: Reidel; 1976.
  3. Sharma PH. Editor and hindi commentator. Kaashyap Samhita, Indriyasthana. 10th ed., Varanasi: Chaukhambha Sanskrit Sansthan; 2005. pp. 98–105.
  4. Pandit Kashinath Shastri, Hindi commentator. Charaka Samhita of Agnivesha, Sharira Sthana, Ch. 2, Ver. 29, 1st ed., Varanasi: Chowkhamba Sanskrit Series Office; 1969. p. 731.
  5. Subramania SV. Bhela Samhita, Sharira Stana, Ch. 3, Ver. 2-4, New Delhi: CCRIM; 1997. p. 175.
  6. Jadavji Trikamji Acahrya, editor. Sushruta Samhita of Sushruta, Sharira Sthana, Ch. 2, Ver. 51-52, Reprint ed. Varanasi: Chowkhamba krishnadas Academy; 2008. p. 349.
  7. Gittelman R, Mannuzza S, Shenker R, et al. Hyperactive boys almost grown up, I: psychiatric status. Arch Gen Psychiatry. 1985;42(10): 937–947.
  8. Dixit SP, Dubey GP. Combined effect of Brahmi, Jyotishmati and Vacha on overall mental performance among mentally retarded children. J Res Ayurveda Siddha 2002;XXIII(1–2):64–70.
  9. Anonymous. The Ayurvedic Formulary of India, Part-I, Section-6. 2nd Revised English ed., Delhi: Dept. of AYUSH, Ministry of H&FW, Govt. of India, pp. 240–242.
  10. Pandit Hari Sastri Paradakara, editor. Ashtang Hridaya of Vagbhata, Uttarasthana, Ch. 6, Ver.26,281-2, Reprint ed. Varanasi: Chaukhamba Orientalia; 2000.
  11. van Karnebeek CDM, Jansweijer MCE, Leenders AGE, et al. Diagnostic investigations in individuals with mental retardation: a systematic literature review of their usefulness. Eur J Hum Genet 2005;13(1):6–25. DOI: 10.1038/sj.ejhg.5201279.
PDF Share