Journal of Research in Ayurvedic Sciences

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VOLUME 3 , ISSUE 3 ( July-September, 2019 ) > List of Articles


Efficacy and Safety of Ayurveda Interventions for Hypothyroidism in 18–60 Years’ Age-group: A Systematic Review Protocol

Neha Dubey, Ekta, Jeuti Rani Das, Girindra Kumar Bora, Bhogavalli Chandrasekhara Rao

Keywords : Galaganda, Hypothyroid, Protocol, Systematic Review,Ayurveda

Citation Information : Dubey N, E, Das JR, Bora GK, Rao BC. Efficacy and Safety of Ayurveda Interventions for Hypothyroidism in 18–60 Years’ Age-group: A Systematic Review Protocol. J Res Ayurvedic Sci 2019; 3 (3):112-116.

DOI: 10.5005/jras-10064-0084

License: CC BY-NC 4.0

Published Online: 00-09-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Introduction: Ayurvedic interventions have been in practice for treatment of thyroid-related disorders alone or in combination with complementary medicine. No systematic review has been conducted for assessing the efficacy and safety of Ayurvedic intervention in hypothyroidism. Present study aimed to provide quality evidence to assess for the efficacy and safety of Ayurveda interventions for hypothyroidism in the 18–60 years’ age-group. Materials and methods: For collection of data, all research article based on randomized controlled trials, multiple-arm clinical trials, nonrandomized clinical trial, quasi-randomized controlled trials having intervention period of at least 12 weeks’ duration will be considered and searched from inception to September 2019 in several databases. Primary outcome will include response to treatment (improvement in subjective criteria of assessment, i.e., hypothyroidism-related symptoms), effect on values of laboratory measures related to thyroid gland functioning like tri-iodothyronine (T3), tetra-iodothyronine (T4), and thyroid-stimulating hormone (TSH) and serious adverse events. Secondary outcome will include measurement of health-related quality of life. Data extraction will be done independently by three reviewers in a predefined format. A narrative synthesis will be conducted for all included study. If extracted data will be eligible for meta-analysis, a meta-analysis will be conducted. Ethics and dissemination: This review does not require formal ethical assessment and approval, as no confidential participant data will be included. Findings will be disseminated widely through publication, conference, and symposia. Study registration no: PROSPERO 2019 CRD42019144799

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  1. Unnikrishnan AG, Kalra S, Sahay RK, et al. Prevalence of hypothyroidism in adults: an epidemiological study in eight cities of India. Indian J Endocrinol Metab 2013;17(4):647–652. DOI: 10.4103/2230-8210.113755.
  2. Jameson JL, Fauci A, Kasper D, et al. Harrison's Principles of Internal Medicine. 19th ed., New York: McGraw Hill Education; 2015.
  3. Ke LQ, Hu Y, Yang K, et al. Chinese herbal medicines for hypothyroidism. Cochrane database of systematic reviews 2015;2:CD008779.
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