Journal of Research in Ayurvedic Sciences

Register      Login

VOLUME 3 , ISSUE 3 ( July-September, 2019 ) > List of Articles

PROTOCOL

A Systematic Review Protocol Evaluating the Efficacy and Safety of Ayurvedic Interventions for Glaucoma

BM Bhavya, Raghvendra Naik, MN Shubhashree

Keywords : Ayurveda, Glaucoma, Intraocular pressure, Systematic review,Adhimanta

Citation Information : Bhavya B, Naik R, Shubhashree M. A Systematic Review Protocol Evaluating the Efficacy and Safety of Ayurvedic Interventions for Glaucoma. J Res Ayurvedic Sci 2019; 3 (3):117-120.

DOI: 10.5005/jras-10064-0087

License: CC BY-NC 4.0

Published Online: 00-09-2019

Copyright Statement:  Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Introduction: The features of glaucoma have similarities with those of Adhimantha as mentioned in Ayurveda, where it exhibits features based on the Doshas involved. The aim of this study is to conduct systematic review of published studies in view of safety and efficacy of Ayurvedic interventions in the management of glaucoma and to run meta-analysis of the published clinical data if sufficient homogeneous studies are available. Materials and methods: This systematic review process would include review of randomized controlled trials (RCTs), quasi-experimental designs, multiple arms clinical trials and observational studies (case series and case control) on the management of glaucoma or Adhimantha through Ayurvedic interventions. Interventions and procedures administered from a minimum of 7 days to maximum of 6 months will be included. Electronic databases search through Ayurvedic research databases and medical journal databases such as MEDLINE, Web of Science, Cochrane register, Scopus, EMBASE, directories of open access journals and hand searching will be done using predefined search terms to identify relevant studies which would include studies done between January 1990 and January 2020. The study selection, data extraction, analysis, and synthesis of results will be done by three researchers. Study selection will follow the symptomatology of Adhimantha/glaucoma as explained in different classical texts of Ayurveda, and the quality of studies will be assessed by the Cochrane risk of bias assessment for RCT and non-RCTs. The heterogeneity of reviewed studies will be evaluated by examining forest plots, and meta-analysis will be planned by using quantitative synthesis if they are sufficiently homogeneous. Ethics approval: Formal ethical approval is not necessary as the primary data of patients will not be collected. The final results of the review will be disseminated through a peer-reviewed publication. PROSPERO registration number: PROSPERO 2019: CRD42019133911.


PDF Share
  1. Duke Elder S. System of Ophthalmology. reprint ed., London: Henry Kimpton; 1976.
  2. Jonas JB, Aung T, Bourne RR, et al. Glaucoma. The Lancet 2017;390(10108):2183–2193. DOI: 10.1016/S0140-6736(17)31469-1.
  3. Trikamji Acharya VY. Sushruta Samhitha of Sushruta, Uttaratantra, ch. 6, Ver. 4-5, Varanasi: Choukhambha Samskrita Samsthana;; 2008. pp. 603–605.
  4. Shastri HS. Astanga Hridaya of Vaghbhata, Uttarasthana, Ch.15, Ver.1-23, Varanasi: Choukhambha Samskrita Samsthana; 2008. pp. 828–830.
  5. Trikamji Acharya VY. Sushruta Samhitha of Sushruta, Uttaratantra, Ch. 6, Ver. 10–20, Varanasi: Choukhambha Samskrita Samsthana; 2008. pp. 603–606.
  6. Shamseer L, Moher D, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ 2015;349(jan02 1):g7647. DOI: 10.1136/bmj.g7647.
  7. Wikipedia contributors. Jadad scale. Wikipedia, The Free Encyclopedia. September 26, 2019, 15:31 UTC. Available at: https://en.wikipedia.org/w/index.php?title=Jadad_scaleandoldid= 918009788. [Last Accessed on 2019 November 6].
  8. Higgins JPT, Altman DG, Sterne JAC. Chapter 8: assessing risk of bias in included studies. In: Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions, Version 5.1.0 (updated March 2011). The Cochrane Collaboration 2011 http://www.cochrane-handbook.org.
  9. Wikipedia contributors. Funnel plot. Wikipedia, The Free Encyclopedia. April 4, 2019, 14:25 UTC. Available at: https://en.wikipedia.org/w/index.php?title=Funnel_plotandoldid= 890931763. [Last Accessed on 2019 November 6].
  10. Muddalwar SS, Pradhan NS. Importance of glaucoma awareness, it's prevention and management in ayurveda. Int Ayurv Med J 2018;6(12):2385–2390. Available from: http://www.iamj.in/posts/images/upload/2385_2390.pdf.
  11. Vishwanath S, Shamsa F. A review on pathogenesis of primary open angle glaucoma: on basis of ayurvedic perspectives. J Biol Sci Opin 2018;6(6):119–123.
  12. Bhat PM, Umale H, Lahankar M. A review on concept of glaucoma in ayurveda and its management. Int J Res Ayurveda Pharm 2018;9(3):159–164. DOI: 10.7897/2277-4343.09383.
  13. Kumar M, Varshney SC, Maurya. OPS. Pathogenesis of glaucoma: integration of biomedical and ayurvedic perspectives. J Res Educ Indian Med 2011;XVII(3-4):115–123.
  14. Kajawe PU, Dudht SG. Role of ayurveda in the management of glaucoma-A review article. World J Pharmac Res 2016;5(4):472–479.
PDF Share