Journal of Research in Ayurvedic Sciences

Register      Login

VOLUME 4 , ISSUE 4 ( October-December, 2020 ) > List of Articles

RESEARCH ARTICLE

Clinical Evaluation of Upanaha with Vachadi Churna in the Management of Osteoarthritis Knee

Deepa Makhija, VC Deep, Sunita Mata, Ramavtar Sharma, KM Pratap Shankar, Vaibhav A Charde, Richa Singhal, Rakesh Rana, Adarsh Kumar, Bharti Gupta, N Srikanth

Keywords : Osteoarthritis, Sandhigatavata, Upanaha, Vachadi Upanaha, Western Ontario and McMaster University Osteoarthritis Index Score

Citation Information : Makhija D, Deep V, Mata S, Sharma R, Shankar KP, Charde VA, Singhal R, Rana R, Kumar A, Gupta B, Srikanth N. Clinical Evaluation of Upanaha with Vachadi Churna in the Management of Osteoarthritis Knee. J Res Ayurvedic Sci 2020; 4 (4):149-157.

DOI: 10.5005/jras-10064-0116

License: CC BY-NC 4.0

Published Online: 11-02-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Background: Osteoarthritis (OA) is a chronic degenerative joint disease and is the commonest form of arthritis. It is the fourth leading cause of disability worldwide. Most of this disability burden is attributable to the involvement of the hips or the knee. Objectives: To assess the clinical efficacy of Upanaha with Vachadi Churna in the management of OA knee concerning pain and stiffness of joints. Materials and methods: It was an open-label, multicentric, single-arm, prospective, clinical study. Sixty subjects of primary OA knee aged between 35 years and 65 years fulfilling the diagnostic criteria of American College of Rheumatology (ACR) for OA knee and showing radiological changes of OA knee were enrolled in the study. Upanaha with Vachadi Churna was done over the affected knee for 14 days. The primary outcome was to see any change in pain and stiffness of joints which was assessed on the visual analog scale (VAS) and Western Ontario and McMaster University Osteoarthritis Index (WOMAC). The assessment was done on the 7th and 14th day and 1 week after completion of therapy, i.e., 21st day. Results: The mean pain score as assessed by VAS, reduced significantly from 64.48 at baseline to 31.95 at the end of the treatment period of 14 days (p value < 0.001). The mean stiffness score assessed on VAS also reduced significantly from 39.68 at baseline to 16.0 after 14 days (p value < 0.001). Significant change in total WOMAC score was also observed, which reduced from mean baseline score of 48.02 to 26.98 till the end of the intervention period of 14 days (p value < 0.001). Significant improvement in cardinal features of osteoarthritis was also observed after completion of therapy. Conclusion: This study substantiates the efficacy of Upanaha with Vachadi Churna in the management of OA knee.


PDF Share
  1. Osteoarthritis Nadkar MY, ed. Golwalla's Medicine for Students. 25th ed., New Delhi: Jaypee Brothers Medical Publishers (P) Ltd; 2017. pp. 662–663.
  2. Osteoarthritis Kasper, Fauci, Hauser, et al., ed. Harrison's Principles of Internal Medicine. 16th ed., New York: McGraw Hill Education; 2015. pp. 2226–2233.
  3. American college of rheumatology recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthri Care Res 2012 2012;64(4):465–474. DOI: 10.1002/acr.21596.
  4. The burden of arthritis and non-steroidalanti-inflammatory treatment. A European literature review. Pharmacoeconomics. 2001;19(1):1–15.
  5. Systematic review of the cost effectiveness of prophylactictreatments in the prevention of gastropathy in patients with rheumatoidarthritis or osteoarthritis taking non-steroidal anti-inflammatory drugs. Ann Rheum Dis 2000;59(10):753–759.
  6. Use of complementary medicines for osteoarthritis—a prospective study. Ann Rheum Dis 2004;63:549–554. DOI: 10.1136/ard.2003.010637.
  7. Arthritis Research UK, July 2014. What Are Complementary and Alternative Treatments? https://www.versusarthritis.org (assessed 20/7/2019).
  8. Charaka Samhita of Agnivesa elaborated by Charaka & Dridhabala with the Ayurveda Dipika commentary by Chakrapani, Chikitsa Sthana, ch. 28, Ver. 37 4th ed., Varanasi: Chowkhambha Sanskrit Sansthan; 1994. p. 618.
  9. Ashtang Hridaya of Vagbhata with Commentaries of Sarvangasundara of Arundatta and Ayurvadarasayana of Hemadri, Nidana Sthana, ch. 15, Ver. 14-15 4th ed., Varanasi: Chowkhamba Sanskrit Series Office; 1995. p. 531.
  10. Ashtang Hridaya of Vagbhata with Commentaries of Sarvangasundara of Arundatta and Ayurvadarasayana of Hemadri, Sutra Sthana, ch. 1, Ver. 11 4th ed., Varanasi: Chowkhamba Sanskrit Series Office; 1995. p. 9.
  11. Ashtang Hridaya of Vagbhata with Commentaries of Sarvangasundara of Arundatta and Ayurvadarasayana of Hemadri, Sutra Sthana, ch. 13, Ver. 1 4th ed., Varanasi: Chowkhamba Sanskrit Series Office; 1995. p. 211.
  12. Sushruta Samhita of Sushruta with English translation of text and Dalhana's Commentary along with critical notes, Chikitsa Sthana, ch. 4, Ver. 8 1st ed., Varanasi: Chaukhambha Vishvabharti; 2000. pp. 304–305.
  13. A clinical study on jatamayadi upanaha sweda in janu sandhigatavata (osteoarthritis of knee joint). J Ayurveda Holis Med 2015;3(6):10–18.
  14. A review on upanayha: an ayurvedic topical application. Int J Res Ayurv Pharm 2016;7(5):22–25.
  15. Radiological assessment of Osteo-Arthrosis. Ann Rheuma Dis 1957;16(4):494–502.
  16. Ashtang Hridaya of Vagbhata with Commentaries of Sarvangasundara of Arundatta and Ayurvadarasayana of Hemadri, Sutra Sthana, ch. 17, Ver. 2-3 4th ed., Varanasi: Chowkhamba Sanskrit Series Office; 1995. p. 253.
  17. Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable. Statisti Met Med Res 2016;25(3):1057–1073.
  18. Risk factors of osteoarthritis knee- A cross-sectional study. J Dent Med Sci 2012;II(5):08–10.
  19. ncbi.nlm.nih.gov .….
  20. com/articles/PMS.htm.
  21. s.r to Osteoarthritis of Knee Joint Synopsis. Dept. of Post Graduate Studies in Panchakarma, Sri Jagadguru Gavisiddeshwar Ayurvedic Medical College & Hospital P.G.Studies & Research Centre, Gavimath campus, Koppal, Karnataka.
  22. Retrospective analysis of clinical studies on sandhigata vata. Int J Pharmaceut Biolog Archiv 2013;4(5):827–832.
  23. Clinical study on the efficacy of karpasa beeja choorna pinda sweda and patra pinda sweda in sandhigata vata. Int Ayurved Med J 2018;6(3):557–565.
  24. Ashtang Hridaya of Vagbhata with Commentaries of Sarvangasundara of Arundatta and Ayurvadarasayana of Hemadri, Chikitsa Sthana, ch. 11, Ver. 6 4th ed., Varanasi: Chowkhamba Sanskrit Series Office; 1995. p. 722.
  25. A review on upanayha: an ayurvedic topical application. Int J Res Ayurveda Pharm 2016;7(5):22–25.
  26. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv 2005;2(1):23–33.
  27. Evaluation of effect of godhumadi upanaha sweda in niramaja katigraha: an open clinical trial. Int J Res Ayurveda Pharm 2017;8(Suppl. 2):139–141.
  28. G. M. p. 73.
  29. Efficacy of dhanyamla sarvanga dhara in the management of obesity: an analytical review. Int J Ayurveda Phar Res 2018;6(6):81–84.
PDF Share