Journal of Research in Ayurvedic Sciences

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2017 | January-March | Volume 1 | Issue 1

ORIGINAL ARTICLE

Vd Kartar Singh Dhiman

Editorial

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:1] [Pages No:0 - 0]

PDF  |  DOI: 10.5005/jras-1-1-vi  |  Open Access |  How to cite  | 

RESEARCH ARTICLE

Rajesh Sannd, HML Meena, Banmali Das, GC Bhuyan, MM Padhi

Clinical Efficacy and Safety of Punarnavadi Mandura and Dadimadi Ghrita in the Management of Iron Deficiency Anemia: A Prospective Open-label Multicenter Study

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:8] [Pages No:1 - 8]

PDF  |  DOI: 10.5005/jp-journals-10064-0001  |  Open Access |  How to cite  | 

Abstract

Background

Iron deficiency anemia is one of the most prevalent types of nutritional disorder in the world. Its etiology is multifaceted and it generally results when the iron demands of the body are not met by iron absorption. Iron deficiency anemia can be symptomatically compared with Pandu Roga in Ayurveda.

Aims and objectives

To evaluate the efficacy and safety of Punarnavadi Mandura and Dadimadi Ghrita in patients suffering from iron deficiency anemia.

Materials and methods

A prospective, open-label multicenter study was carried out at three peripheral centers of the Central Council for Research in Ayurvedic Sciences. One hundred three patients satisfying the selection criteria were enrolled from the outpatient department of these centers and were administered Punarnavadi Mandura (500 mg) and Dadimadi Ghrita (10 gm) twice daily before food with lukewarm water for 12 weeks. Follow-up was done finally after 2 weeks without medication. However, data of 90 patients were used for analysis. Hematological parameters, viz., hemoglobin, mean corpuscular hemoglobin concentration, mean corpuscular volume, packed cell volume, total iron-binding capacity, serum ferritin, and serum iron, were assessed at baseline, 42nd day, and at the end of the treatment period of 12 weeks (i.e., 84th day). Paired sample t-test was used to compare mean change from baseline with the 84th day. A p-value of <0.05 was considered significant.

Results

At the end of 12 weeks, compared with baseline, statistically significant increase was observed in mean serum iron level (p-value = 0.005). However, mean change from baseline to 84th day in hemoglobin level (p-value = 0.325) was not significant. A significant improvement in symptoms of anemia, such as weakness, fatigue, dizziness, and headache, was also seen. The treatment was found to be safe and effective in the patients with iron deficiency anemia as all the safety parameters were within the stipulated range. No adverse drug reaction or adverse events were reported during the trial period.

Conclusion

Punarnavadi Mandura and Dadimadi Ghrita administered together in the above-mentioned dose were found effective and safe in patients suffering from iron deficiency anemia.

How to cite this article

Sannd R, Meena HML, Das B, Yadav B, Dua P, Khanduri S, Rana R, Singhal R, Bhuyan GC, Ota S, Srikanth N, Padhi MM, Dhiman KS. Clinical Efficacy and Safety of Punarnavadi Mandura and Dadimadi Ghrita in the Management of Iron Deficiency Anemia: A Prospective Open-label Multicenter Study. J Res Ayurvedic Sci 2017;1(1):1-8.

RESEARCH ARTICLE

Rinku Tomar, Indira Kumari, Vilas Gangurde, MM Padhi

Clinical Efficacy and Safety of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the Management of Menopausal Syndrome: A Prospective Open-label Multicenter Study

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:8] [Pages No:9 - 16]

PDF  |  DOI: 10.5005/jp-journals-10064-0002  |  Open Access |  How to cite  | 

Abstract

Introduction

The menopausal period comprises about one-third of average women's life. During this period, women are vulnerable to conditions caused by estrogen deficiency from short-term discomfort to long-term health problems.

Aim

To evaluate the clinical efficacy of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the management of menopausal syndrome and to evaluate changes in the quality of life in women.

Materials and methods

This trial was a multicenter single-arm study conducted at three Institutes of Central Council for Research in Ayurvedic Sciences. One hundred fifteen women aged between 40 and 55 years with Kupperman menopausal index score ≥15, follicle-stimulating hormone ≥20 IU/L, and endometrial thickness ≤5 mm were included in the study. Three Ayurvedic classical formulations, viz., Ashokarishta, Ashvagandha Churna and Pravala Pishti, were administered for 12 weeks followed by subsequent 2 weeks without intervention follow-up. Outcome measures were changes in menopausal symptoms using menopause rating scale (MRS) and improvement in the quality of life using menopause-specific quality of life (MENQOL) questionnaire and they were assessed at the baseline, 84th day, and at the end of 2 weeks after the completion of intervention period. Paired sample t-test was used to compare mean change from baseline to 84th day. A p-value <0.05 was considered significant.

Results

The findings of the study reveal that the effect of therapy has shown statistically significant decrease in MRS total score (p-value <0.001). The mean MRS total score at the baseline was 22.43 and decreased to 5.29 after treatment at 84th day, and further reduced to 5.06 at the 14th week (follow-up period without trial interventions). The improvements of MENQOL in four domains, viz., vasomotor, psychosocial, sexual, and physical, at the end of 12th week and 14th week were also significant (p-value <0.001) in comparison with the baseline. Further, all the safety parameters like liver function tests and kidney function tests remained within the normal limits throughout the trial period and no adverse events or adverse drug reaction were reported, which confirm the clinical safety of the trial drugs.

Conclusion

Ashokarishta, Ashvagandha Churna and Pravala Pishti are found to be safe and effective in the management of menopausal syndrome.

How to cite this article

Tomar R, Sharma S, Kumari I, Gangurde V, Ota S, Dua P, Khanduri S, Yadav B, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. Clinical Efficacy and Safety of Ashokarishta, Ashvagandha Churna and Pravala Pishti in the Management of Menopausal Syndrome: A Prospective Open-label Multicenter Study. J Res Ayurvedic Sci 2017;1(1):9-16.

RESEARCH ARTICLE

KR Kishore, PKS Nair, SK Giri, BS Sharma, MM Padhi

Clinical Efficacy and Safety of Vyoshadi Guggulu and Haritaki Churna in the Management of Obesity: A Prospective Open-label Multicenter Study

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:8] [Pages No:17 - 24]

PDF  |  DOI: 10.5005/jp-journals-10064-0003  |  Open Access |  How to cite  | 

Abstract

Background

Obesity is a medical condition in which excess body fat has accumulated to the extent that it may have a negative effect on health. Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility. Obesity can be compared with a condition called sthaulya in Ayurveda.

Aims and objectives

To evaluate the efficacy and safety of Vyoshadi Guggulu and Haritaki Churna in patients suffering from obesity (sthaulya).

Materials and methods

A prospective, open-label multicenter study was carried out at three peripheral centers of the Central Council for Research in Ayurvedic Sciences. A total of 165 obese patients satisfying the selection criteria were enrolled from the outpatient department of these centers and were administered Vyoshadi Guggulu (1.5 gm) twice daily before food with lukewarm water and Haritaki Churna (3 gm) twice a day before food for 12 weeks. Patients were also followed after 2 weeks of without medication period. Body mass index (BMI), waist circumference, hip circumference, and 36-item Short Form (SF-36) health survey questionnaire were assessed at an interval of 14 days each till 12 weeks (i.e., 84 days) and at the end of without drug follow-up period at 14th week. Paired sample t-test was used to compare mean change in BMI, waist circumference, and hip circumference from baseline to the 84th day. A p-value <0.05 was considered significant.

Results

At the end of treatment period of 84 days as compared with baseline, a statistically significant change in BMI, waist circumference, hip circumference, and waist–hip ratio was observed (p-value <0.001). A significant reduction in serum cholesterol level was also observed from a mean value of 187.79 at baseline to 183.84 at 84th day (p-value <0.022). Moreover, a significant improvement in all the eight domains of SF-36 health survey questionnaire was also observed (p-value <0.001)

Conclusion

Vyoshadi Guggulu and Haritaki Churna administered together in the above-mentioned dose were found effective and safe in patients suffering from obesity.

How to cite this article

Kishore KR, Ravte RK, Nair PKS, Giri SK, Sharma BS, Dua P, Khanduri S, Yadav B, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. Clinical Efficacy and Safety of Vyoshadi Guggulu and Haritaki Churna in the Management of Obesity: A Prospective Open-label Multicenter Study. J Res Ayurvedic Sci 2017;1(1):17-24.

RESEARCH ARTICLE

Harbans Singh, Rajesh Sannd, Laxman W Bhurke, Krishna Kumari, Renu Singh, SK Vedi, Bharti  , MM Padhi

An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:9] [Pages No:25 - 33]

PDF  |  DOI: 10.5005/jp-journals-10064-0004  |  Open Access |  How to cite  | 

Abstract

Background

Vatarakta vis-à-vis gout is a common condition in both primary care and specialist practice. Gout is a systemic disease characterized by manifestations of chronic under­lying hyperuricemia, resulting in the deposition of monosodium urate crystals in various tissues. Gout is the most common of the crystal induced arthritis due to disturbed uric acid metabolism and precipitation of urate crystals in extracellular space of joints, periarticular tissue, bones, and other organs.

Aim and objective

To explore the therapeutic efficacy and safety of Amrita Guggulu and Pinda Taila in the management of hyperuricemia in gout (Vatarakta) patients.

Materials and methods

A total of 100 cases (25–65 years) of primary gouty arthritis fulfilling the diagnostic criteria as recommended by the American College of Rheumatology were selected for the present study from outpatient department of the Central Ayurveda Research Institute for Respiratory Disorders Patiala and Regional Ayurveda Research Institute for Urinary Disorders, Jammu, India, irrespective of their sex, religion, and socioeconomic status. Only those patients who presented themselves with at least 6 of 12 criteria of American College of Rheumatology (1977) were selected for the clinical trial. Amrita Guggulu was given 1000 mg twice daily orally and Pinda Taila was applied locally 10 mL twice daily for 84 days.

Results

The trial therapy was assessed based on the improvement in clinical features, Visual Analog Scale (VAS) score, Patient's Global Assessment Scale score, Physician's Global Assessment Scale Score, SF-36 Health Survey Score for quality of life (QOL), and biochemical parameters. Each patient was subjected to routine blood test, serum uric acid, liver function tests, and renal function tests before treatment, after 28 days of treatment, and after 84 days of treatment. The trial combination showed statistically significant improvement in the clinical manifestations, QOL as well as reduction in marker of hyperuricemia, i.e., serum uric acid; the mean serum uric acid at the baseline was 7.76 mg/dL, which was reduced to 6.50 mg/dL after the trial period of 84 days. There was also decrease in the level of VAS score, Patient's Global Assessment Scale score, and Physician's Global Assessment Scale score. There were no impairment in liver function test and renal function test, indicating the good safety profile of trial therapy.

Conclusion

Hence, Amrita Guggulu and Pinda Taila drug combination is an effective and safe remedy for gouty arthritis (Vatarakta) patients.

How to cite this article

Singh H, Sannd R, Bhurke LW, Kumari K, Singh R, Vedi SK, Kumar A, Bharti, Rana R, Singhal R, Srikanth N, Padhi MM, Dhiman KS. An Open Label Efficacy Study of Amrita Guggulu and Pinda Taila in the Management of Hyperuricemia in Gout (Vatarakta) Patients. J Res Ayurvedic Sci 2017;1(1):25-33.

RESEARCH ARTICLE

MM Padhi

A Cross-sectional Community-based Study on Healthcare seeking Behavior of Elderly Women for Urogenital Symptoms

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:6] [Pages No:34 - 39]

PDF  |  DOI: 10.5005/jp-journals-10064-0005  |  Open Access |  How to cite  | 

Abstract

Introduction

Sociological literature indicates gender differentiation in both health status and use of health services. It has been observed that women did not complain of any medical problem until it started interfering with their daily activities. Therefore, a cross-sectional community-based survey was conducted in lower socioeconomic group areas of Delhi to document the health care-seeking behavior of elderly women for urogenital symptoms and also to explore the reasons that influence them.

Aim and objective

The study aimed at documenting the health care-seeking behavior of elderly women belonging to lower socioeconomic group for urogenital symptoms and also to improve their health care-seeking behavior by using information education and communication (IEC) and behavior change communication (BCC) strategy.

Materials and methods

Stratified random sampling technique was applied for selection of 5 zones out of the 12 Municipal Corporation of Delhi (MCD) zones. The zones were selected according to their size by using probability proportional to size sampling. The list of colonies was taken from the website of MCD. Then an equal number of 20 colonies from this list was selected by simple random sampling from each of the five zones. From these 100 colonies, a total of 824 women aged 50 years and above were identified through snowball sampling and were interviewed with the help of an interviewer administered questionnaire.

Results

Analysis of responses of representative sample of 824 women aged 50 and above in statistically selected low socioeconomic areas of National Capital Territory of Delhi revealed that 479 (58.1%) of the women were found to be suffering from urogenital problems. From these 479 women who suffered from urogenital problems, nearly 271 (56.6%) did not report the problem to their family members and 262 (54.8%) did not report it to doctors.

Conclusion

Based on the results of this survey, it was concluded that many elderly women do not report about their urogenital symptoms neither to their family members nor to doctors for various reasons. Therefore, the women should be made aware about the existence of effective screening and health care facilities for their problems. They should be educated about the ways to prevent these problems. The IEC and BCC strategies should be used in the lower socioeconomic group areas to improve the health care-seeking behavior of elderly women for urogenital symptoms. Steps should be taken to improve the accessibility and affordability of the services.

How to cite this article

Bhat S, Yadav B, Singhal R, Srikanth N, Padhi MM, Singh R, Dhiman KS. A Cross-sectional Community-based Study on Healthcare seeking Behavior of Elderly Women for Urogenital Symptoms. J Res Ayurvedic Sci 2017;1(1):34-39.

RESEARCH ARTICLE

Sulochana Bhat, Vikas Gupta, MM Padhi

Approaches for integrating Ayurveda with Conventional System in a Multispeciality Hospital for Management of Osteoarthritis (Knee)

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:8] [Pages No:40 - 47]

PDF  |  DOI: 10.5005/jp-journals-10064-0006  |  Open Access |  How to cite  | 

Abstract

Introduction

Udupa Committee Report 1958, Indian Health Policy 1983, National Population Policy 2000, ISM and H Policy 2002, and the National Rural Health Mission are some of the policy recommendations for mainstreaming of Ayurveda, Yoga and Naturopathy, Unani, Siddha, and Homoeopathy. Based on these recommendations, the physical mainstreaming for patient care and research is established but is not popularized in some hospitals and among health care providers due to various reasons.

Aim

To study the feasibility of integrating Ayurveda with allopathic system in the management of Osteoarthritis (OA) (knee).

Materials and methods

This operational study was conducted at Safdarjung Hospital, New Delhi, India, in collaboration with the World Health Organization, India office. The study covered 252 patients of OA knee, out of which 201 completed the study. For the management of OA, standardized Yogaraja Guggulu, Ashwagandha, and Narayan taila were used along with lifestyle and dietary recommendations.

Results

Among 201 patients who completed the study period of 8 weeks, there was statistically significant improvement in signs and symptoms, King George's Medical College (KGMC)and Visual Analog Scale (VAS) scores (p-value < 0.05). There was statistically significant reduction in the intake of rescue medicines and side effects of oral nonsteroidal anti-inflammatory drug. The study could develop referrals from orthopedics department to Ayurvedic unit for management of OA knee.

Conclusion

It was evident from the study that the Ayurvedic treatment is effective in the management of OA. It also concluded that continued communication and scientific approaches will ascertain actual integration and there is good scope for developing integration model in the management of OA. The Ayurveda health care providers were able to establish functional integration with their allopathic counterparts and were able to manage cross referrals.

How to cite this article

Bhat S, Gupta V, Srikanth N, Padhi MM, Rana R, Singhal R, Dhiman KS. Approaches for integrating Ayurveda with Conventional System in a Multispeciality Hospital for Management of Osteoarthritis (Knee). J Res Ayurvedic Sci 2017;1(1):40-47.

Review

CCRAS RESEARCH POLICY: A PROFILE

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:25] [Pages No:48 - 72]

PDF  |  DOI: 10.5005/jp-journals-10064-0007  |  Open Access |  How to cite  | 

ORIGINAL ARTICLE

LIST OF CCRAS PUBLICATIONS AVAILABLE BOOKS FOR SALE

[Year:2017] [Month:January-March] [Volume:1] [Number:1] [Pages:7] [Pages No:73 - 79]

PDF  |  DOI: 10.5005/jras-1-1-73  |  Open Access |  How to cite  |