Journal of Research in Ayurvedic Sciences

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2018 | October-December | Volume 2 | Issue 4

EDITORIAL

Focus on Capacity Building in R&D of AYUSH

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:1] [Pages No:0 - 0]

PDF  |  DOI: 10.5005/jp-journals-10064-0204-iv  |  Open Access |  How to cite  | 

RESEARCH ARTICLE

P Radhakrishna, Bhagwan Sahai Sharma

Clinical Evaluation of Yogaraj Guggulu, Gandharvahasta Taila, and Dhanwantara Taila in the Management of Osteoarthritis Knees

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:8] [Pages No:209 - 216]

Keywords: Dhanwantara taila, Gandharvahasta taila, Osteoarthritis, Sandhigatavata, Western Ontario and McMaster University osteoarthritis score,Yogaraj guggulu

PDF  |  DOI: 10.5005/jp-journals-10064-0060  |  Open Access |  How to cite  | 

Abstract

Background: Osteoarthritis (OA) is a chronic degenerative joint disease and is the most common form of arthritis. It is the fourth leading cause of disability worldwide. Most of this disability burden is attributable to the involvement of hips or knees. Objective: The aim of the present study was to assess the clinical efficacy of Ayurvedic formulations in the management of OA knees. Materials and methods: It was an open label, multicenter, prospective, and clinical study. One hundred and twenty subjects of primary OA knees aged between 35 and 65 years, fulfilling the diagnostic criteria of the American College of Rheumatology (ACR) and showing radiological changes, were enrolled in the study. Yogaraj guggulu (500 mg) thrice a day with lukewarm water after food along with Gandharvahasta taila (6 mL) orally with lukewarm water just before bedtime and Dhanwantara taila for external application twice a day were given for 12 weeks. The assessment was done every 4 weeks. The primary outcome was assessed by seeing the change in the total Western Ontario and McMaster University osteoarthritis (WOMAC) score. Results: WOMAC score and clinical symptoms were reduced significantly from baseline to the end of the treatment. Conclusion: This study revealed the efficacy of Yogaraj guggulu along with Gandharvahasta taila and Dhanwantara taila in the management of OA knees.

RESEARCH ARTICLE

Banamali Das, Rohit Kumar Ravte, G Venkateswarlu, Purnendu Panda

Clinical Efficacy and Safety of Brahma Rasayana in Apparently Healthy Elderly Persons: A Prospective Multicenter Open-label Study

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:8] [Pages No:217 - 224]

Keywords: Brahma Rasayana, Dhatu Poshana, Hamilton depression rating scale,Rasa Dhatu

PDF  |  DOI: 10.5005/jp-journals-10064-0061  |  Open Access |  How to cite  | 

Abstract

Background: Rasayana therapy is one of the branches of Ayurveda, which aims at promoting the excellence of Dhatu, improving inherent defense mechanisms in our body, and improving general health. Aim: To assess the clinical efficacy and safety of Brahma Rasayana in apparently healthy elderly persons. Materials and methods: The clinical study was undertaken at three peripheral institutes in different geographical areas. One hundred and eighty apparently healthy elderly persons fulfilling the inclusion criteria were enrolled in the study. Brahma Rasayana was administered orally in the dose of 15 grams twice a day on empty stomach with lukewarm milk for a period of 12 weeks (84th day). Parameters, like the Hamilton depression rating scale, PGI Memory Scale, WHO Quality of Life-BREF Scale, hematological parameters, lipid profile, liver function tests, renal function tests, thyroid stimulating hormone (TSH), serum calcium, and serum vitamin D3 level, were assessed before and after the administration of therapy. The paired t test was applied to compare mean changes from baseline to the 84th day. Results: A statistically significant effect (p < 0.0001) was observed at the end of the 84th day on all the four domains of the WHOQOL-BREF score, PGI Memory Scale, Hamilton depression rating scale, and chief complaints at the end of 12 weeks, compared with the baseline. Nonsignificant changes in blood parameters were obtained, proving the safety of the test drug. Also, the significant increase in the serum vitamin D3 level and decrease in the fasting blood sugar level were observed. Conclusion: Brahma Rasayana was found to be effective, safe, and tolerable in apparently healthy elderly volunteers.

RESEARCH ARTICLE

Kiran Kale, Prem Lal Bharati, Babita Yadav, MN Suryawanshi, Kshirod Kumar Ratha, Bhagwan Sahai Sharma

Clinical Efficacy and Safety of Kushmandaka Rasayana in the Management of Chronic Bronchitis: A Prospective Open Label Multicenter Study

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:8] [Pages No:225 - 232]

Keywords: Clinical COPD questionnaire, FEV1%,Kaphaja Kasa

PDF  |  DOI: 10.5005/jp-journals-10064-0062  |  Open Access |  How to cite  | 

Abstract

Background: Prevalence of chronic bronchitis is increasing as a part of urbanization and increased pollution. Failure of timely recognition of the condition often causes worsening of the disease. In Ayurveda, the symptoms of chronic bronchitis may be compared with those of Kaphaja Kasa. Kushmandaka Rasayana is a medicine that is commonly used in respiratory diseases owing to its Rasayana effect. Objectives: To evaluate the clinical efficacy and safety of Kushmandaka Rasayana in chronic bronchitis. Materials and methods: A prospective, open-label multicenter study was carried out in three peripheral centers of the Central Council for Research in Ayurvedic Sciences (CCRAS). A total of 193 patients with chronic bronchitis (Kaphaja Kasa) satisfying the selection criteria were enrolled from the outpatient department of these centers and were administered with 10 g of Kushmandaka Rasayana twice daily with lukewarm water for 12 weeks, and the patients were followed up, every two weeks up to the 12th week and at the 14th week (without medication follow-up). Changes in the symptoms, clinical COPD questionnaire (CCQ), and forced expiratory volume in the first second (FEV1%), were assessed every 14 days till 12 weeks and at the end of 14 weeks and were compared with baseline data. A p value of <0.05 was considered as significant. Safety assessment was done by analyzing liver function test (LFT) and renal function test (RFT) parameters before and after the trial. Result: Statistically significant improvement was observed in clinical symptoms, FEV1, and CCQ questionnaire without any adverse drug reactions (ADR)/adverse events (AE). All safety parameters were within normal limits during the entire trial.

RESEARCH ARTICLE

Mandip R Goyal, Anup B Thakar, Shilpa B Donga, Divyarani Kathad

Role of Shodhana with Haritakyadi Yoga in Increasing Sperm Count in the Case of Oligozoospermia: An Open-labeled Clinical Trial

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:7] [Pages No:233 - 239]

Keywords: Ayurveda, Haritakyadi yoga, Oligozoospermia, Shodhana, Total sperm count, Vajikarana.

PDF  |  DOI: 10.5005/jp-journals-10064-0063  |  Open Access |  How to cite  | 

Abstract

Aim and objectives: Infertility is often defined as the inability to conceive after 12 months of regular sexual intercourse without the use of birth control. Around 10% of women aged 25–44 years are estimated to have difficulty conceiving or staying pregnant. Worldwide, 8–12% of couples experience fertility problems. Between 45% and 50% of cases are thought to stem from factors that affect men. Oligozoospermia refers to semen with a low concentration of sperm and is a common finding in male infertility. Hence, the present clinical trial was planned to assess the role of Shodhana (biocleansing) performed by Haritakyadi Yoga in increasing the sperm count in the case of oligozoospermia. Vajikarana therapy improves the nourishment and function of the reproductive organs and vitalizes tissues of the reproductive organs, increasing semen potency specially administered after Shodhana (biocleansing). Haritakyadi Yoga is mentioned in the Rasayana chapter of Charaka Samhita for the purpose of Shodhana (biocleansing) before administration of Rasayana and Vajikarana (aphrodisiac) drugs. Materials and methods: For the clinical study, 93 male patients suffering from primary or secondary infertility for more than one year and having sperm count less than 15 million/mL were selected irrespective of religion and caste. The effect of the therapy was assessed by the status of seminal parameters before and after the Shodhana procedure. Results and discussion: Performing Shodhana (biocleansing) with Haritakyadi Yoga induced Vamana (emesis) and Virechana (purgation) with a moderate type of Shuddhi in a maximum number of treated patients. It also provided a statistically significant increase in the total sperm count (71.24%), sperm motility (16.82%), semen volume (47.14 mL), serum luteinizing hormone (LH) (19.84%), serum follicle stimulating hormone (FSH) (33.09%), and serum testosterone (20.56%). Conclusion: Results of the present clinical trial indicates that performing Shodhana (biocleansing) with the Haritakyadi Yoga procedure is effective in the case of oligozoospermia.

CASE REPORT

Rajkala P Patil

Ayurvedic Management of Osteoarthritis Knee with Grade IV Severity and Obesity (Avaranajanya Janu-Sandhigatavata with Sthoulya)

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:7] [Pages No:240 - 246]

Keywords: Avarana, Obesity, Osteoarthritis knee,Sandhigatavata, Sthoulya.

PDF  |  DOI: 10.5005/jp-journals-10064-0064  |  Open Access |  How to cite  | 

Abstract

This case illustrates the effective mode of Ayurvedic therapeutic intervention in a chronic osteoarthritis (OA) knee patient with Grade IV severity and obesity, where the regular use of analgesics was reported and surgery was advised. A 60-year old male presented with complaints of severe pain in both the knee joints for the past 11 years, associated with swelling, difficulty to walk, limited movement of knee joints with deformity, loss of sleep due to pain, being unable to perform major activities of daily living with an increased dependency for personal care, and loss of income. The present case was diagnosed as OA knee and the severity was graded as Grade IV. The patient was diagnosed as associated with obesity. On Ayurvedic parlance, the present case was diagnosed as Avaranajanya Janu- Sandhigatavata with Sthoulya based on the etiology and signs and symptoms. The patient was treated with a combination of Ayurvedic oral medications and treatment procedures. After the course of treatment, the patient felt much better with knee joint pain, swelling, and stiffness, and was able to walk without support and without pain for 500 m, able to climb stairs, and do minor household work. Improvement was noted on the Western Ontario and McMaster Universities (WOMAC) OA index score from 78 to 27 (right knee) and 73 to 29 (left knee); the activepain visual analog scale (VAS) score from 10 to 5, body weight from 76 to 65 kg, waist circumference from 112 to 100 cm, and body mass index (BMI) from 28.6 to 24.5 kg/m2. Furthermore, the patient was able to withdraw the use of analgesics and avoid surgery.

CASE REPORT

Neelam Kumari Singh, Alok Singh Sengar, Bipin Bihari Khuntia

Management of Garbhastravi Vandhya (Repeated Abortion) with Ayurvedic Intervention: A Case Report

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:7] [Pages No:247 - 253]

Keywords: Basti, Garbhastravi vandhya, Guduchi ghanavati, Phalaghrita, Recurrent abortion

PDF  |  DOI: 10.5005/jp-journals-10064-0065  |  Open Access |  How to cite  | 

Abstract

Garbhastravi Vandhya (Repeated abortion) has been described by Harita Samhita under infertility. It was critically reviewed in the context of certain Jataharinis, Putraghani, and Asrija Yonivyapada, which denotes repeated abortions. Three or more consecutive spontaneous abortion before 20 weeks are defined as recurrent miscarriages. The common causes of the first trimester abortion are genetic factors, immune and endocrine factors, infection, and unexplained ones in the majority of cases. The available conventional treatments are hormonal therapy, heparin injection and immunotherapy which are associated with high rates of treatment failure and complications. In this case report patient suffered from repeated first trimester abortion 5 times with secondary infertility for 3 years. As the complete investigations were normal, diagnosis towards unexplained recurrent abortions was made. In the preconceptional period, the patient was treated with Lekhana Basti for 10 days along with Ayurvedic medication of Kanchnara Guggulu, Arogyavardhini Vati, and Ashokarishta for 45 days. With these medications, the patient got conceived, and then Phalaghrita and Guduchi Ghanavati were given for the whole gestational period. The patient had full-term pregnancy without any complication and delivered a healthy baby. Panchakarma along with Ayurvedic medicines offers a good approach to manage recurrent abortion. But, to establish this fact, further study on larger samples is required.

CASE REPORT

Emy S Surendran, M Akash Lal, KM Pratap Sankar

Conservative Management of Young Age Onset Pelvic Organ Prolapse through Ayurvedic Management: A Case Report

[Year:2018] [Month:October-December] [Volume:2] [Number:4] [Pages:5] [Pages No:254 - 258]

Keywords: Ayurveda, Pelvic organ prolapse,Prasramsini, Yoni pichu, Yoni prakshalana

PDF  |  DOI: 10.5005/jp-journals-10064-0066  |  Open Access |  How to cite  | 

Abstract

Pelvic organ prolapse (POP) is a condition characterized by the descent or herniation of pelvic organs from their normal site of attachment. It is common in postmenopausal women. Rarely does it develop in the younger age group as a complication of pregnancy. Prolapse may be persisting or relapsing after labor. If left untreated, it will progress into procidentia and ulcer formation. Hysterectomy and pelvic floor repair are the conventional methods for the management of this condition. Prasramsini is a paithika yoniroga characterized by the displacement of uterus and excessive vaginal discharges. Ladies having a history of duprasava or difficult labor are more prone to develop Prasramsini. Acharyas have explained abhyanthara and sthanika chikitsas aiming at the conservative management of this condition. A 26-year-old married lady came to the out patient department (OPD) with complaints of mass per vagina along with increased per vaginal discharge and difficulty in urination. She had been diagnosed with the second degree uterine prolapse, grade II cystocele and grade II rectocele, and was suggested for hysterectomy by a gynecologist. An attempt was made to manage the case conservatively by the treatment principles of Prasramsini yonivyapath. Sthanika chikitsas like yoni kshalana, yoni pichu dharana along with internal administration of medicines were tried. These were found to be effective in managing the symptoms and reducing the protrusion of mass per vagina. Ayurvedic treatment principles can be utilized as a conservative method of management in uncomplicated and early stages of POP. Hysterectomy and associated morbidities can be avoided, especially in patients of a younger age group.